Eeyore: A Novel Mouse Model of Hereditary Deafness

Eeyore: A Novel Mouse Model of Hereditary Deafness

Animal models that recapitulate human disease are proving to be an invaluable tool in the identification of novel disease-associated genes. These models can improve our understanding of the complex genetic mechanisms involved in disease and provide a basis to guide therapeutic strategies to combat these conditions. We have identified a novel mouse model of non-syndromic sensorineural hearing lo...

Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness.

Hearing loss is the most widespread sensory disorder, with an incidence of congenital genetic deafness of 1 in 1600 children. For many ethnic populations, the most prevalent form of genetic deafness is caused by recessive mutations in the gene gap junction protein, beta 2, 26 kDa (GJB2), which is also known as connexin 26 (Cx26). Despite this knowledge, existing treatment strategies do not comp...

Hereditary Deafness Newsletter

Hereditary Deafness Newsletter

Hereditary Deafness Newsletter